Common causes of error in Engineering Analysis

We are working on an exam paper on SolidWorks Simulation and came across a question:

What are the common assumptions which deviate the analysis solution from actual loading results in real-life?

We tried to answer it as: Difference between Material Distribution in actual part and model in software, Difference between physical constraining of part and oversimplified constraints in the software,  Difference between actual load pattern and simplified loading patterns in software, Difference between location of actual loading on part and loading in software model.

It would be great if someone adds assumptions we have missed

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